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16bit Sensation: Another Layer is similar to Thermae Romae Novae

Let's see... person born in a specific period in time (Ancient Rome and Modern Japan) who have aspirations of great significance (being one of the greatest bath house architects in Rome and being a big-time game illustrator) who were displaced in Heisei-era Japan and are enthralled with the technological aspects of that period (public baths and bishojo game development) and decide to introduce what they've learned to that time period.

-- RamRol97

Drugstore in Another World: The Slow Life of a Cheat Pharmacist is similar to Parallel World Pharmacy

Guy in another world runs a pharmacy.

Contrast: Reiji Kirio was an ordinary salaryman at the time of his teleportation and when he was, he was endowed with pharmaceutical superpowers. Pharma de Médicis was once Kanji Yakutani who died of karoshi and got reincarnated in another world; he possesses chemistry-related powers.

-- RamRol97

Daily Lives of High School Boys is similar to Wasteful Days of High School Girls

Same comedy concept, different gender.

-- RamRol97

Battle Athletes Victory is similar to Extreme Hearts

If you're into cute girls doing hi-tech sporty things, then you may want to watch these 2 series. The contrast though is that Battle Athletes Victory focuses more on individual sports while Extreme Hearts is more into team sports.
Also, "initially inexperienced lead crossing the road to glory" storyline.

-- RamRol97

Chainsaw Man is similar to Jujutsu Kaisen

Chainsaw Man and Jujutsu Kaisen both start with the main protagonist merging/combining with a demon or devil; CM's being Pochita and Denji, JJK's being Yuuji and Sukuna. Jujutsu Kaisen and Chainsaw Man see the protagonists as someone/thing that needs to be eliminated but will let them live on certain conditions, such as fighting against devils on a team or finishing what they started with the merge concerning a demon.

-- not_another_word

Girls' Frontline is similar to GODDESS OF VICTORY: NIKKE

Gunslinging gynoids? Check.
Post-apocalyptic setting? Check.
Varied amounts of fanservice? Check.
Mobile gacha games? Checkaroo.

-- RamRol97

Mega Man Zero is similar to Mega Man ZX

ZX is the direct sequel to the Zero series

-- RiskyZ

The Loud House is similar to Danchigai

The protagonist is his parents' only son.

-- MUshiromiya1977

Bullied ~Revenge Hypnosis~ is similar to Saimin Seishidou

The same author wrote the source material for both OVA. Similar protagonists as both are overweight. The same studio animated each series. Hypnosis is a plot point in both.

-- Pluto34

Anohana is similar to Orange

Orange and AnoHana are both short drama series with 12 episodes and a movie. They also both have a supernatural twist.

-- hello_I_exist

A Silent Voice is similar to Words Bubble Up Like Soda Pop

Both are anime movies with romance and drama.

-- hello_I_exist

Toradora! is similar to Horimiya

Horimiya and Toradora! are both short romances with elements of comedy and drama.

-- hello_I_exist

Kimba, the white Lion (manga) is similar to Jungle Emperor: The Brave Can Change the Future

Ova of Jungle Emperor Leo

-- Ben6439

Kimba the White Lion is similar to Jungle Emperor: The Brave Can Change the Future

Ova of Jungle emperor Leo

-- Ben6439

Story of Seasons is similar to Harvest Moon: The Tale of Two Towns

Both games are produced by Yoshifumi Hashimoto and feature Kamil and Licorice

-- jakobhenerey21

Flame of Recca is similar to YuYu Hakusho

First arc of Flame of Recca (tournament arc) copies extensively from Yu Yu Hakusho's Dark Tournament Saga. Also both series composed of a team of main characters (Flame of Recca used to have 4 mains just like Yu Yu Hakusho until a 5th member joined the party later on) and the main lead has a girlfriend who he must save from time to time.

-- DaiSenpaiSama

Estrus Exorcist! ~Serving a Young Lady Who Goes Into Heat When She Purifies.~ is similar to Tonarino Maou Tsukai

Domination

-- Kioute23654987

Kantai Collection is similar to Touken Ranbu

Both are an RNG-based military strategy game with same gameplay elements but a different setting:
KanColle - WW2 ships as girls fighting an abyssal organization bent on world domination
TouRabu - Feudal Japanese swords as boys fighting a retrograde force aimed on altering history, and sometimes a mysterious force that doesn't want any interference in the space-time continuum
Both are published by DMM.com, but have different developers - Kadokawa Games for KanColle, while Nitroplus for TouRabu.

-- RamRol97

Bishoujo Senshi vs Hagure Orc Buntai is similar to JK to Orc Heidan

A parallel story.
The same artist did the series and have the same orc antagonists.

-- lincasito

Tokimeki Memorial Only Love is similar to Twin Love

Both series have a similar feel, along with both focusing on romance, comedy and drama.

-- Karasu87

Kyou Kara Maou! is similar to The Familiar of Zero (Series)

Both are isekais with horrible tsunderes abusing their love interest

-- maou

Persona 4 Arena Ultimax is similar to Persona 4 - The Ultimate in Mayonaka Arena

Ultimax is Arena's sequel,and takes place the day after Arena.

-- pyromania

Shin Megami Tensei: Devil Summoner: Soul Hackers is similar to Shin Megami Tensei (Series)

Devil Summoner: Soul Hackers is an entry in the Shin Megami Tensei Series

-- pyromania

Shin Megami Tensei: Persona 5 is similar to Shin Megami Tensei (Series)

Persona 5 is an entree in the Shin Megami Tensei Series

-- pyromania

Shin Megami Tensei: Persona 5 is similar to Shin Megami Tensei: Persona 4

Persona 5 is a sequel to Persona 4, and is set about 5 years after Persona 4.

-- pyromania

YuYu Hakusho is similar to Bleach

Yu Yu Hakusho is Bleach, but shorter and with less filler. Both series feature a student, juvenile delinquent who meets a female shinigami and ends up working with that shinigami (who decides to also go to his school often) to help spirits travel to to afterlife. The series then changes to a battle shounen and the protagonist teams up with his friends to fight monsters.

Showing any more similarity crosses into spoiler territory, but the main difference between the series is that YYH focuses more on developing the characters.

-- AnneAuthor

Mother Daughter is similar to Monobeno -Happy End-

The protagonist of this series also has a sister and a childhood friend, and that childhood friend has a mother who is a subject of infidelity.

-- SourNote2014

Space Adventure Cobra is similar to Cobra the Animation

Cobre:The Animation is related to Space Adventure Cobra

-- king_Julius007

Hellsing is similar to Tokyo Ghoul

Both series deal with relations between human and non-human characters (vampires and ghouls) who live and work side-by-side. They both feature lots of violent, bloody battles with supernatural elements.

-- PunkHazard

Paranoia Agent is similar to Boogiepop Phantom

Both series are psychological thrillers that weave together several stories and feature a mysterious assailant.

-- PunkHazard

Tekkonkinkreet is similar to Akira

Both movies are set in a futuristic metropolis and follow young boys/teenagers who are members of street gangs. Both are fast-paced and violent with supernatural elements, but are essentially stories of friendship between two boys. They are both enhanced by rich, atmospheric music soundtracks.

-- PunkHazard

CANAAN is similar to Jormungand

Both series star ruthless, white-haired child assassins who are emotionally detached due to their violent pasts, but who others feel drawn to and depend on.

-- PunkHazard

Ninja Scroll is similar to Samurai Champloo

Both series take place in a distorted version of feudal Japan and feature two warriors/samurai and a young woman who are brought together by chance and embark on a journey together.

-- PunkHazard

Cowboy Bebop is similar to Trigun

Both are effectively Sci-fi Westerns. The main characters are both skilled fighters who have a complicated past and although they are really laid back, trouble seems to follow them around.

-- PunkHazard

Kyou Kara Maou! is similar to Legend of the Legendary Heroes

Both are adventure/fantasy/comedies with supernatural elements and take place in a feudal setting.

-- PunkHazard

Cowboy Bebop is similar to Space Dandy

Both series follow the exploits of an oddball crew of space bounty-hunters.

-- PunkHazard

Paranoia Agent is similar to Perfect Blue

They are both surreal psychological thrillers from the director Satoshi Kon.

-- PunkHazard

Noragami is similar to Blood Lad

Both series feature male characters with supernatural powers, who have a close relationship with a human-ghost girl.

-- PunkHazard

Moyasimon: Tales of Agriculture is similar to Tsuritama

Both are slice of life comedies with touch of science-fiction. Both are centred around a schoolboy and his odd assortment of friends.

-- PunkHazard

My Hero Academia is similar to One Punch Man

Both series are comedies that involve organizations of heroes with unique, sometimes strange, abilities, costumes, and names. Both main characters are also outliers among the heroes - Saitama is extremely over-powered, while Izuku is the only hero at the academy without powers.

-- AmaterasuWings

Seraph of the End is similar to Attack on Titan (Series)

Same animation studio. Same basic concept - after humanity has degraded, one species has pretty much overcome the human race - Titans in AoT, Vampires in OnS. A young guy (Eren, Yuuichirou) vows to kill all of the members of the threatening species (Titans, Vampires) in a quest for revenge for dead loved ones.

-- AmaterasuWings

Nabari no Ou is similar to Chrono Crusade

Both centre around a person using up their lifeforce whenever they fight and people trying to save them from that fate.

-- LiCobra

Yamada-kun and the Seven Witches is similar to Fushigi Yuugi

Both series have Suzaku as the main God (school, for Yamada-kun to 7-nin no Majo) in which the protagonists siding with, and both animes has their protagonist gathering seven peoples in order to have their wishes granted. Both animes also deals with a book that has the informations about the warriors or witches. And they are also deals with time travel (Ancient China, for Miaka and Yui. And near past, for Ryu and Jin)

-- hikaruaizora

Gonna be the Twin-Tail!! is similar to Nyaruko: Crawling With Love

Similar purely by how crazy the plot is.

-- Rei

The Irregular at Magic High School is similar to Magical Girl Lyrical Nanoha (Series)

Pretty similar magic system, various adjustable magic devices.

-- Akikojam

No Game, No Life is similar to Problem children are coming from another world, aren't they?

Both take characters from our world and throw them into a fantasy world where their super OP powers save the universe by playing games.

-- Rei

Aesthetica of a Rogue Hero is similar to The Irregular at Magic High School

Badass, seriously OP main character.

-- Rei

Demon Lord Dante is similar to Devil Lady

So many things are similar here: Character design; main theme(humans turning into monsters); smash cut zoom musical cues; and close ups on the eyes.
Given the fact that both series are the brainchild of Go Nagai, explains the similarities, as well as his expert way of telling so much with a mere close up of the eyes.
Spoiler: I found Devil Lady to be better with it's richer story line, but Dante has better plot twists.

-- Mitsugu

Angel Tales is similar to Popotan

After viewing this again the music gave it away. There's a lot of similarity to the character design, and musical cues on top of the OST(excluding the main themes). The plot style isn't too dissimilar, though Angel Tales has no nudity or time travel. They're also both semi-quick series AT:13 eps + a bonus while Popotan: just 12.

-- Mitsugu

Sword Art Online is similar to Accel World

Same real world, just different years. Accel World is several years in the future from SAO.

-- Rei


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